To confirm ankylosing spondylitis (AS) in its early stages, even if the HLA-B27 test is negative, the following tests can be considered:

1. C-reactive Protein (CRP) Levels:
- Measures the amount of inflammation in the body.
- High CRP levels can support a diagnosis of AS, though they are not definitive on their own.

To confirm ankylosing spondylitis (AS) in its early stages, even if the HLA-B27 test is negative, the following tests can be considered:

1. C-reactive Protein (CRP) Levels:
- Measures the amount of inflammation in the body.
- High CRP levels can support a diagnosis of AS, though they are not definitive on their own.

2. Erythrocyte Sedimentation Rate (ESR):
- Another marker of inflammation that can be elevated in AS.

3. Imaging Tests:
- X-rays: Can show changes in the sacroiliac joints and spine.
- MRI: More sensitive than X-rays, can detect early inflammation and changes in the sacroiliac joints and spine.

4. Clinical Evaluation:
- A thorough physical examination and assessment of symptoms by a healthcare provider.

These tests, combined with a clinical evaluation, can help in diagnosing AS even if the HLA-B27 test is negative.

 This AI-generated response comes from MySpondylitisTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

Blood Tests for Inflammation: Which Results Point to Spondylitis? | MySpondylitisTeam

HLA-B27 and the Genetics of Spondylitis | MySpondylitisTeam