I took Humira for +10 years and this didn’t happen to me. There are other TNF inhibitors that may not cause this side effect.

Nonetheless all biologicals can have side effects that are different in different people. Some can be serious in more rare occasions.

I had this rash too, but it wasn’t from the Humira, I think it was just part of the AS and I was told it can happen if you have too much sun exposure. I had it all over a few times, not itchy just like you said but warm and blotchy. I did go away on its own after a few days or so.

We each and all react differently and uniquely to our treatments whatever they are. Options can include trialling alternate treatments, or even time as the body gets used to the drug in our system.

Options may also include trialling an alternate time of day, or even sequence prior point of injection, and even diet can alter our bodily reactions.

I've had to give up on some foods and have minimised or even achieved nil negative responses to some of my meds. I have a hot shower prior, to all my injection points, and inject on an evening when I'm usually more relaxed. The injections have warmed to room temperature And my injection points have been most successful (for me) high in my upper thigh.

There are many variables we can use to advantage to get the best out of what meds we can use. It's can be a matter of trialling and being open and aware to options.

Also, it's also being aware of negative effects as you've mentioned that other and further medical intervention may be appropriate. Hoping you'll find your solution that works for you.

I had the raised hot injection site reaction from humira, taltz, and now enrbrel . It doesn't happen in the initial injection just in the ones after. I figured its my body's way of trying to defend itself. I take different antihistamines like famotidine and Claritin. I usually get the reaction only on my legs. But I am not willing to give up on the meds due to the benefit of ways the side effect for me